Symbol
Name
ID

Nr4a2
nuclear receptor subfamily 4, group A, member 2
MGI:1352456

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Hyposmia

Spasticity

Bradykinesia

Tremor

Depression

Anxiety

Panic attack

Hallucinations

Apathy

Reduced social reciprocity

Impulsivity

Agitation

Restless legs

Cognitive impairment

Dementia

Frontal lobe dementia

Short attention span

Insomnia

Hyperreflexia

Dyskinesia

Dystonia

Gait imbalance

Postural instability

Abnormal autonomic nervous system physiology

Disease(s) Associated with NR4A2

Parkinson's disease

Mouse Phenotypes		nervous system phenotype	increased midbrain apoptosis	abnormal midbrain development	abnormal substantia nigra morphology	abnormal tegmentum morphology	abnormal nervous system development	abnormal dopaminergic neuron morphology	decreased dopaminergic neuron number	loss of dopaminergic neurons	neuron degeneration
Availability	Mouse Genotype	nervous system phenotype	increased midbrain apoptosis	abnormal midbrain development	abnormal substantia nigra morphology	abnormal tegmentum morphology	abnormal nervous system development	abnormal dopaminergic neuron morphology	decreased dopaminergic neuron number	loss of dopaminergic neurons	neuron degeneration
	Nr4a2^tm1Niko/Nr4a2^tm1Niko	*
	Nr4a2^tm1Omc/Nr4a2^tm1Omc
	Nr4a2^tm1Tpe/Nr4a2^tm1Tpe
	Nr4a2^tm1Omc/Nr4a2⁺
	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn Slc6a3^tm1(cre)Lrsn/Slc6a3^tm1(cre)Lrsn (conditional)
	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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